Van de Ven Brace Halts Everton's Run at Brand New Home Ground
Micky van de Ven emerged as the initial backline player to net twice in a Premier League game for Spurs since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr nets third in dying moments
This loss is Everton's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Spurs extended their winning streak in away games in the top division and delivered the Toffees their first defeat at their new home.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain Van de Ven struck twice from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to turn it around before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - nodded in a final goal to put the game to bed.
Jake O'Brien thought he had levelled the scores five minutes after the defender's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a series of excellent saves to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the goal on the pitchside monitor and the official decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team up to third in the Premier League, five points off local foes and table-toppers the Gunners.
Everton stay 14th and sit six points clear of the drop zone.
Tottenham analysis: The defender fulfils role at each end of the field
After a uninspiring weekday display in the Champions League against Monaco, where they mustered a only two shots on target, the manager chose Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being substituted for Richarlison after an hour on the field, but it turns out he wasn't needed in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Spurs' first goal came from a well-worked corner routine, with Rodrigo Bentancur directing the ball back across the face of goal for an unmarked Van de Ven to score.
And the captain - stepping up as captain in the Argentine's absence - notched his next goal in added time as he rose above Jordan Pickford to nod in.
Van de Ven was equally impressive in defensive duties, combining well with his defensive colleague as the pair dealt excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Everton missing striker's instinct
Everton's new home had been a fortress, but it appears the freshness may have worn off somewhat and fans headed to the exits after the midfielder's third for Tottenham.
The break in the team's unbeaten home run will not be a massive worry for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' two recognised strikers - had netted just a single goal combined before the weekend's outing.
And they were failed to contribute to that poor record on a wet and gloomy night on Merseyside.
Beto's performance was epitomized when he chose to bicycle-kick a clear chance from near the goal, despite having space and opportunity to reposition for a more conventional attempt that would have challenged the keeper.
The substitute, as well, was unable to make an impact after coming on for Beto in the 65th minute.
It was not for a lack of chance. Most of the home side's offensive moves came through Grealish and the forward, who tirelessly delivered threatening crosses into the Tottenham penalty area.
What next for both teams?
Everton: The team head to Sunderland in the top flight on early November at 20:00 GMT.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.